>>Fazeli E, Child DD, Bucks SA, Stovarsky M, Edwards G, Rose SE, Yu CE, Latimer C, Kitago Y, Bird T, Jayadev S, Andersen OM, Young JE. A familial missense variant in the Alzheimer's Disease gene SORL1 impairs its maturation and endosomal sorting. bioRxiv [Preprint]. 2023 Nov 13:2023.07.01.547348. doi: 10.1101/2023.07.01.547348. PMID: 37461597; PMCID: PMC10349966.

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>>Mishra S, Knupp A, Kinoshita C, Williams CA, Rose SE, Martinez R, Theofilas P, Young JE. Pharmacologic enhancement of retromer rescues endosomal pathology induced by defects in the Alzheimer's gene SORL1. Stem Cell Reports. 2023 Dec 12;18(12):2434-2450. doi: 10.1016/j.stemcr.2023.10.011. Epub 2023 Nov 9. PMID: 37949073; PMCID: PMC10724056.

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>>Shin YJ, Evitts KM, Jin S, Howard C, Sharp-Milgrom M, Schwarze-Taufiq T, Kinoshita C, Young JE, Zheng Y. Amyloid beta peptides (Aβ) from Alzheimer's disease neuronal secretome induce endothelial activation in a human cerebral microvessel model. Neurobiol Dis. 2023 Jun 1;181:106125. doi: 10.1016/j.nbd.2023.106125. Epub 2023 Apr 14. PMID: 37062307.

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>> Mishra S, Knupp A, Szabo MP, Williams CA, Kinoshita C, Hailey DW, Wang Y, Andersen OM, Young JE. The Alzheimer's gene SORL1 is a regulator of endosomal traffic and recycling in human neurons. Cell Mol Life Sci. 2022 Feb 28;79(3):162. doi: 10.1007/s00018-022-04182-9. PMID: 35226190; PMCID: PMC8885486.

 

>> Frankowski H, Yeboah F, Berry BJ, Kinoshita C, Lee M, Evitts K, Davis J, Kinoshita Y, Morrison RS, Young JE. Knock-Down of HDAC2 in Human Induced Pluripotent Stem Cell Derived Neurons Improves Neuronal Mitochondrial Dynamics, Neuronal Maturation and Reduces Amyloid Beta Peptides. Int J Mol Sci. 2021 Mar 3;22(5):2526. doi: 10.3390/ijms22052526. PMID: 33802405; PMCID: PMC7959288.

 

>> Szabo MP, Mishra S, Knupp A, Young JE. The role of Alzheimer's disease risk genes in endolysosomal pathways. Neurobiol Dis. 2021 Dec 3;162:105576. doi: 10.1016/j.nbd.2021.105576. Epub ahead of print. PMID: 34871734.

 

>> Knupp A, Mishra S, Martinez R, Braggin JE, Szabo M, Kinoshita C, Hailey DW, Small SA, Jayadev S, Young JE. Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing. Cell Rep. 2020 Jun 2;31(9):107719. doi: 10.1016/j.celrep.2020.107719. PubMed PMID: 32492427; PubMed Central PMCID: PMC7409533.

 

>> D'Souza GX, Rose SE, Knupp A, Nicholson DA, Keene CD, Young JE. The application of in vitro-derived human neurons in neurodegenerative disease modeling. J Neurosci Res. 2020 Mar 13;. doi: 10.1002/jnr.24615. [Epub ahead of print] Review. PubMed PMID: 32170790; PubMed Central PMCID: PMC7487003.

 

>> Rose SE, Frankowski H, Knupp A, Berry BJ, Martinez R, Dinh SQ, Bruner LT, Willis SL, Crane PK, Larson EB, Grabowski T, Darvas M, Keene CD, Young JE. Leptomeninges-Derived Induced Pluripotent Stem Cells and Directly Converted Neurons From Autopsy Cases With Varying Neuropathologic Backgrounds. J Neuropathol Exp Neurol. 2018 May 1;77(5):353-360. doi: 10.1093/jnen/nly013. PubMed PMID: 29474672; PubMed Central PMCID: PMC6018913.